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Article

Leveraging auxiliary data from arbitrary distributions to boost GWAS discovery with Flexible cFDR.

PLoS genetics - 1 Oct 2021

Hutchinson Anna, Reales Guillermo, Willis Thomas, Wallace Chris

Abstract excerpt

Genome-wide association studies (GWAS) have identified thousands of genetic variants that are associated with complex traits. However, a stringent significance threshold is required to identify robust genetic associations. Leveraging relevant auxiliary covariates has the potential to boost statistical power to exceed the significance threshold. Particularly, abundant pleiotropy and the non-random distribution of...

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PMID: 34669738
DOI: 10.1371/journal.pgen.1009853
PMCID: PMC8559959

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