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Article

The Development of Disease-Modifying Therapies for Osteoarthritis (DMOADs): The Evidence to Date.

Drug design, development and therapy - 1 Jan 2021

Oo Win Min, Little Christopher, Duong Vicky, Hunter David J

Abstract excerpt

Osteoarthritis (OA) is a complex heterogeneous articular disease with multiple joint tissue involvement of varying severity and no regulatory-agency-approved disease-modifying drugs (DMOADs). In this review, we discuss the reasons necessitating the development of DMOADs for OA management, the classifications of clinical phenotypes or molecular/mechanistic endotypes from the viewpoint of targeted drug discovery,...

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Identifiers

PMID: 34262259
DOI: 10.2147/DDDT.S295224
PMCID: PMC8273751

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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