Article

Adipocyte-Specific Ablation Of PU.1 Promotes Energy Expenditure and Ameliorates Metabolic Syndrome In Aging Mice

2021-08-29

Abstract excerpt

<h4>ABSTRACT</h4> <h4>Objective</h4> Although PU.1/Spi1 is known as a master regulator for macrophage development and function, we have reported previously that it is also expressed in adipocytes and is transcriptionally induced in obesity. Here, we investigated the role of adipocyte PU.1 in the development of age-associated metabolic syndrome. <h4>Methods</h4> We generated mice with adipocyte specific PU.1 kno...

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Literature Corpus work: 64889a5f-e61c-5cbc-a6b9-7ddea7d138ec
DOI: 10.1101/2021.08.29.458103

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