Article

Engineering substrate selectivity in the human sodium/iodide symporter (NIS)

2025-10-08

Abstract excerpt

Iodide (I - ) uptake mediated by the Na⁺/I - symporter (NIS) is the first step in the biosynthesis of the thyroid hormones, of which I - is an essential constituent. NIS couples the inward transport of I - against its electrochemical gradient to the inward translocation of Na + down its electrochemical gradient. NIS also transports oxyanions (XO 4 - s), such as perrhenate (ReO 4 - ) and the environmental po...

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Literature Corpus work: 3b96c918-782e-505c-9a38-692b15c63fb5
DOI: 10.1101/2025.10.07.681042

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