Article

MAPK pathway inhibitors enhance radioiodine sensitivity in anaplastic thyroid carcinoma through promoting NIS expression and ARF4-mediated NIS membrane transport

2026-02-18

Abstract excerpt

<title>Abstract</title> <p> <bold>Objective:</bold> Anaplastic thyroid cancer (ATC) patient develops resistance to radioactive iodine (RAI) due to diminished sodium-iodide symporter (NIS) expression and mislocalization to the cell membrane. MAPK pathway inhibitors have demonstrated efficacy in enhancing RAI avidity in radioiodine-refractory papillary thyroid carcinoma and ATC. Elucidating this mechanism may lea...

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Literature Corpus work: 813fa22e-4a28-589f-9499-c6bb51e21217
DOI: 10.21203/rs.3.rs-8501287/v1

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