Article

PML and PML-like exonucleases restrict retrotransposons in jawed vertebrates

2022-07-30

Abstract excerpt

<h4>ABSTRACT</h4> We have uncovered a novel role for the promyelocytic leukemia ( PML ) gene and novel PML-like DEDDh exonucleases in the maintenance of genome stability through the restriction of LINE-1 (L1) retrotransposition in jawed vertebrates. Although the PML tumour suppressor protein in mammals is SUMOylated and forms nuclear bodies, we found that the spotted gar PML ortholog and related proteins in fish...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work: 646b46ae-5de8-517e-baab-ffe006d1977e
DOI: 10.1101/2022.07.29.501749

Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest

PML and PML-like exonucleases restrict retrotransposons in jawed vertebratesDOI 10.1101/2022.07.29.501749Read

PML: Regulation and multifaceted function beyond tumor suppressionSemantic proximity Read

Roles of retrovirus-derived PEG10 and PEG11/RTL1 in mammalian development and evolution and their involvement in human diseaseSemantic proximity Read

A role for PML and the nuclear body in genomic stabilitySemantic proximity Read

PML nuclear bodies contribute to the basal expression of the mTOR inhibitor DDIT4Semantic proximity Read

The functional roles of PML nuclear bodies in genome maintenanceSemantic proximity Read

The Imprinted Retrotransposon-Like Gene PEG11 (RTL1) Is Expressed as a Full-Length Protein in Skeletal Muscle from Callipyge SheepSemantic proximity Read

Functional Connection between Rad51 and PML in Homology-Directed RepairSemantic proximity Read

Characterization of Endogenous Human Promyelocytic Leukemia IsoformsSemantic proximity Read

The function, regulation and therapeutic implications of the tumor suppressor protein, PMLSemantic proximity Read

PML nuclear bodies: regulation, function and therapeutic perspectivesSemantic proximity Read

The PML-Interacting Protein DAXX: Histone Loading Gets into the PictureSemantic proximity Read

Interaction of the Epstein-Barr Virus mRNA Export Factor EB2 with Human Spen Proteins SHARP, OTT1, and a Novel Member of the Family, OTT3, Links Spen Proteins with Splicing Regulation and mRNA ExportSemantic proximity Read