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Article

PML nuclear bodies contribute to the basal expression of the mTOR inhibitor DDIT4

23 Mar 2017

Abstract excerpt

Abstract The promyelocytic leukemia (PML) protein is an essential component of PML nuclear bodies (PML NBs) frequently lost in cancer. PML NBs coordinate chromosomal regions via modification of nuclear proteins that in turn may regulate genes in the vicinity of these bodies. However, few PML NB-associated genes have been identified. PML and PML NBs can also regulate mTOR and cell fate decisions in response to...

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PMID: 28332630
DOI: 10.1038/srep45038

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