Article

Spatially precise neuron formation via hydrogel mediated modulation of the host astrocyte response

2025-12-22

Abstract excerpt

The regenerative capacity of the central nervous system after injury or disease is limited. Advancements in genetic and epigenetic reprogramming of non-neuronal cells into induced neurons presents a promising strategy for neuronal replacement and circuit reconstruction yet is hindered by suboptimal reprogramming efficacy. Here, we have achieved high astrocyte-to-neuron reprogramming efficacy through the ectopic ex...

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Literature Corpus work: 1975289c-1271-5d95-90f5-6b9432bdab28
DOI: 10.64898/2025.12.20.695501

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