Article

Tryptophan C-mannosylation is critical for Plasmodium falciparum transmission

2022-02-16

Abstract excerpt

<title>Abstract</title> <p>C-mannosylation stabilizes proteins bearing a thrombospondin repeat (TSR) domain in metazoans. Here we show that <italic>Plasmodium falciparum</italic> expresses a DPY19 C-mannosyltransferase in the endoplasmic reticulum and that <italic>DPY19</italic>-deficiency abolishes C-glycosylation, destabilizes members of the TRAP adhesin family and inhibits transmission to mosquitoes. <italic>P...

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Literature Corpus work: 644c8ede-a7ee-53ce-a533-bb11a26ff5d5
DOI: 10.21203/rs.3.rs-1358538/v1

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