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Protein O-fucosylation in Plasmodium falciparum ensures efficient infection of mosquito and vertebrate hosts

11 Sept 2017

Abstract excerpt

O-glycosylation of the Plasmodium sporozoite surface proteins CSP and TRAP was recently identified, but the role of this modification in the parasite life cycle and its relevance to vaccine design remain unclear. Here, we identify the Plasmodium protein O-fucosyltransferase (POFUT2) responsible for O-glycosylating CSP and TRAP. Genetic disruption of POFUT2 in Plasmodium falciparum results in ookinetes that are...

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PMID: 28916755
DOI: 10.1038/s41467-017-00571-y

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