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The lectin-specific activity of <i>Toxoplasma gondii</i> microneme proteins 1 and 4 binds Toll-like receptor 2 and 4 N-glycans to regulate innate immune priming

2017-09-12

Abstract excerpt

<h4>ABSTRACT</h4> Infection of host cells by Toxoplasma gondii is an active process, which is regulated by secretion of microneme (MICs) and rhoptry proteins (ROPs and RONs) from specialized organelles in the apical pole of the parasite. MIC1, MIC4 and MIC6 assemble into an adhesin complex, secreted on the parasite surface and function to promote infection competency. MIC1 and MIC4 are known to bind terminal sia...

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Literature Corpus work
a4b7bdd7-ca4a-5259-b771-93fa8ee1e7bf
DOI
10.1101/187690
Open publication

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The lectin-specific activity of <i>Toxoplasma gondii</i> microneme proteins 1 and 4 binds Toll-like receptor 2 and 4 N-glycans to regulate innate immune primingDOI 10.1101/187690
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