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Tryptophan C-mannosylation is critical for Plasmodium falciparum transmission

29 Jul 2022

Abstract excerpt

Tryptophan C-mannosylation stabilizes proteins bearing a thrombospondin repeat (TSR) domain in metazoans. Here we show that Plasmodium falciparum expresses a DPY19 tryptophan C-mannosyltransferase in the endoplasmic reticulum and that DPY19-deficiency abolishes C-glycosylation, destabilizes members of the TRAP adhesin family and inhibits transmission to mosquitoes. Imaging P. falciparum gametogenesis in its...

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PMID: 35906227
DOI: 10.1038/s41467-022-32076-8

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