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Article

Age-dependent increase in Kalirin-9 and Kalirin-12 transcripts in human orbitofrontal cortex.

The European journal of neuroscience - 1 Oct 2016

Grubisha Melanie J, Lin Chien-Wei, Tseng George C, Penzes Peter, Sibille Etienne, Sweet Robert A

Abstract excerpt

KALRN (KAL) is a Rho GEF that is highly involved in regulation of the actin cytoskeleton within dendrites. There are several isoforms of the protein that arise from differential splicing of KALRN's 66 exons. KAL isoforms have different functions in development. For example, overexpression of the KAL9 and KAL12 isoforms induce dendritic elongation in early development. However, in mature neurons KAL9...

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Identifiers

PMID: 27471199
DOI: 10.1111/ejn.13351
PMCID: PMC5048532

Genes

KALRN

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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