Article
Large-Scale Identification of Common Trait and Disease Variants Affecting Gene Expression.
American journal of human genetics - 1 Jun 2017
Hauberg Mads Engel, Zhang Wen, Giambartolomei Claudia, Franzén Oscar, Morris David L, Vyse Timothy J, Ruusalepp Arno, Sklar Pamela, Schadt Eric E, Björkegren Johan L M, Roussos Panos
Abstract excerpt
Genome-wide association studies (GWASs) have identified a multitude of genetic loci involved with traits and diseases. However, it is often unclear which genes are affected in such loci and whether the associated genetic variants lead to increased or decreased gene function. To mitigate this, we integrated associations of common genetic variants in 57 GWASs with 24 studies of expression quantitative trait loci...
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