Article

Logical modeling of dendritic cells <i>in vitro</i> differentiation from human monocytes unravels novel transcriptional regulatory interactions

2020-08-14

Abstract excerpt

Dendritic cells are the major specialized antigen-presenting cells, thereby connecting innate and adaptive immunity. Because of their role in establishing adaptive immunity, they have been used as targets for immunotherapy. Monocytes can differentiate into dendritic cells in vitro in the presence of colony-stimulating factor 2 (CSF2) and interleukin 4 (IL4), activating four signalling pathways (MAPK, JAK/STAT, NF...

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Literature Corpus work: 63f67659-c1d4-585e-9e7a-fbbf5f84f108
DOI: 10.1101/2020.08.14.251710

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