Article

A STAT5B-driven mouse model of hepatosplenic γδ T-cell lymphoma reveals therapeutic efficacy of JAK inhibition

2025-10-26

Abstract excerpt

Hepatosplenic T-cell lymphoma (HSTCL) is a rare and aggressive neoplasm associated with poor responses to standard chemotherapy regimens and low survival rates. No targeted therapies are available for HSTCL, and preclinical models to test new treatment options have not been established. The JAK-STAT signaling cascade is a key dysregulated pathway in HSTCL, and STAT5B N642H is the most frequent somatic mutation i...

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Literature Corpus work: 63ed8313-02d3-55b8-8a57-a1eca1e40e0b
DOI: 10.1101/2025.10.24.684333

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