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The Genetic Basis of Hepatosplenic T-cell Lymphoma

25 Jan 2017

Abstract excerpt

Abstract Hepatosplenic T-cell lymphoma (HSTL) is a rare and lethal lymphoma; the genetic drivers of this disease are unknown. Through whole-exome sequencing of 68 HSTLs, we define recurrently mutated driver genes and copy-number alterations in the disease. Chromatin-modifying genes, including SETD2, INO80, and ARID1B, were commonly mutated in HSTL, affecting 62% of cases. HSTLs manifest frequent mutations in...

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PMID: 28122867
DOI: 10.1158/2159-8290.cd-16-0330

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