Article
JAK-STAT and G-protein-coupled receptor signaling pathways are frequently altered in epitheliotropic intestinal T-cell lymphoma.
Leukemia - 1 Jun 2016
Nairismägi M-L, Tan J, Lim J Q, Nagarajan S, Ng C C Y, Rajasegaran V, Huang D, Lim W K, Laurensia Y, Wijaya G C, Li Z M, Cutcutache I, Pang W L, Thangaraju S, Ha J, Khoo L P, Chin S T, Dey S, Poore G, Tan L H C, Koh H K M, Sabai K, Rao H-L, Chuah K L, Ho Y-H, Ng S-B, Chuang S-S, Zhang F, Liu Y-H, Pongpruttipan T, Ko Y H, Cheah P-L, Karim N, Chng W-J, Tang T, Tao M, Tay K, Farid M, Quek R, Rozen S G, Tan P, Teh B T, Lim S T, Tan S-Y, Ong C K
Abstract excerpt
Epitheliotropic intestinal T-cell lymphoma (EITL, also known as type II enteropathy-associated T-cell lymphoma) is an aggressive intestinal disease with poor prognosis and its molecular alterations have not been comprehensively characterized. We aimed to identify actionable easy-to-screen alterations that would allow better diagnostics and/or treatment of this deadly disease. By performing whole-exome sequencing...
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