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Mitochondrial dysfunction and oxidative stress in Parkinson’s disease: mechanisms, biomarkers, and therapeutic strategies

14 Aug 2025

Abstract excerpt

BACKGROUND: Parkinson's disease (PD) is the second most common neurodegenerative disorder, characterized by motor symptoms and progressive degeneration of dopaminergic neurons. Accumulating evidence indicates that mitochondrial dysfunction and oxidative stress are major contributors to PD pathogenesis. OBJECTIVES: This review explores the molecular mechanisms underlying PD, emphasizing mitochondrial dysfunction...

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PMID: 40813952
DOI: 10.1080/21688370.2025.2537991

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