Article

Regulation of protein abundance in neurons by selective translation of 3′UTR isoforms

2026-07-09

Abstract excerpt

The precise regulation of protein synthesis is essential for cellular function and survival. In particular, in neurons, dysregulated mRNA translation is linked to impaired memory formation and is a hallmark of neurodegenerative diseases. Neurons are characterized by tissue-specific, long 3′ untranslated regions (3′UTRs); in this study, we demonstrate that mRNA isoforms with these neuronal 3′UTRs are less efficient...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work: 63d77f95-a546-5470-8421-b1bd31c6bcbd
DOI: 10.64898/2026.07.08.737200

Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest

Regulation of protein abundance in neurons by selective translation of 3′UTR isoformsDOI 10.64898/2026.07.08.737200Read

5' UTR length shapes alternative N-terminal protein isoforms across cancers and in rare disease.Semantic proximity Read

Regulation of mRNA Translation in Neurons—A Matter of Life and DeathSemantic proximity Read

Nonsense-mediated mRNA decay in neuronal physiology and neurodegenerationSemantic proximity Read

5′ UTR length regulates alternative N-terminal protein isoform production in health and diseaseSemantic proximity Read

Unraveling the Pathways to Neuronal Homeostasis and Disease: Mechanistic Insights into the Role of RNA-Binding Proteins and Associated FactorsSemantic proximity Read

ELAV mediates 3' UTR extension in the Drosophila nervous system.Semantic proximity Read

Messenger RNA Translation Defects in Neurodegenerative DiseasesSemantic proximity Read

Neuronal RNA ‐binding proteins in health and diseaseSemantic proximity Read

Translation dysregulation in neurodegenerative diseases: a focus on ALSSemantic proximity Read

Overlapping Activities of ELAV/Hu Family RNA Binding Proteins Specify the Extended Neuronal 3' UTR Landscape in Drosophila.Semantic proximity Read

Altered mRNA transport and local translation in i3Neurons with RNA-binding protein knockdownSemantic proximity Read

Some like it translated: small ORFs in the 5′UTRSemantic proximity Read