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Article

Overlapping Activities of ELAV/Hu Family RNA Binding Proteins Specify the Extended Neuronal 3' UTR Landscape in Drosophila.

Molecular cell - 1 Oct 2020

Wei Lu, Lee Seungjae, Majumdar Sonali, Zhang Binglong, Sanfilippo Piero, Joseph Brian, Miura Pedro, Soller Matthias, Lai Eric C

Abstract excerpt

The tissue-specific deployment of highly extended neural 3' UTR isoforms, generated by alternative polyadenylation (APA), is a broad and conserved feature of metazoan genomes. However, the factors and mechanisms that control neural APA isoforms are not well understood. Here, we show that three ELAV/Hu RNA binding proteins (Elav, Rbp9, and Fne) have similar capacities to induce a lengthened 3' UTR landscape in an...

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Identifiers

PMID: 33007254
DOI: 10.1016/j.molcel.2020.09.007
PMCID: PMC7546445

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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