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Selective targeting of epigenetic reader domains

6 Mar 2017

Abstract excerpt

INTRODUCTION: Epigenetic regulators including writers, erasers, and readers of chromatin marks have been implicated in numerous diseases and are therefore subject of intense academic and pharmaceutical research. While several small-molecule inhibitors targeting writers or erasers are either approved drugs or are currently being evaluated in clinical trials, the targeting of epigenetic readers has lagged behind....

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PMID: 28277835
DOI: 10.1080/17460441.2017.1303474

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