Article

Detection of Normal and Chimeric Nucleophosmin in Human Cells

1999-01-15

Abstract excerpt

In anaplastic large-cell lymphoma (ALCL), the (2;5) chromosomal translocation creates a fusion gene encoding the 80-kD NPM-ALK hybrid protein. This report describes three new monoclonal antibodies, two of which recognize, by Western blotting, the N-terminal portion of NPM present in the NPM-ALK fusion protein and also in two other NPM fusion proteins (NPM-RAR and NPM-MLF1). The third antibody recognizes the C-ter...

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Identifiers and source

Literature Corpus work: 637f9a8c-07f3-562d-a54c-cae8ece8cef5
DOI: 10.1182/blood.v93.2.632.402k15_632_642

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