Article
The oncogenic fusion protein nucleophosmin-anaplastic lymphoma kinase (NPM-ALK) induces two distinct malignant phenotypes in a murine retroviral transplantation model.
Oncogene - 24 Jul 2003
Miething Cornelius, Grundler Rebekka, Fend Falco, Hoepfl Josef, Mugler Claudia, von Schilling Christoph, Morris Stephan W, Peschel Christian, Duyster Justus
Abstract excerpt
A t(2;5) (p23;q35) chromosomal translocation can be found in a high percentage of anaplastic large-cell lymphomas (ALCL). This genetic abnormality leads to the expression of the NPM-ALK fusion protein, which encodes a constitutively active tyrosine kinase that plays a causative role in lymphomagenesis. Employing a modified infection/transplantation protocol utilizing an MSCV-based vector, we were able to...
Topics
- Animals
- Cell Separation
- DNA, Complementary
- Disease Models, Animal
- Flow Cytometry
- Green Fluorescent Proteins
- Luminescent Proteins
- Mice
- Models, Genetic
- Neoplasm Transplantation
- Neoplasms, Experimental
- Phenotype