Article
Role of the nucleophosmin (NPM) portion of the non-Hodgkin's lymphoma-associated NPM-anaplastic lymphoma kinase fusion protein in oncogenesis.
Molecular and cellular biology - 1 Apr 1997
Bischof D, Pulford K, Mason D Y, Morris S W
Abstract excerpt
The NPM-ALK fusion gene, formed by the t(2;5)(p23;q35) translocation in non-Hodgkin's lymphoma, encodes a 75-kDa hybrid protein that contains the amino-terminal 117 amino acid residues of the nucleolar phosphoprotein nucleophosmin (NPM) joined to the entire cytoplasmic portion of the receptor tyr...
Topics
- Anaplastic Lymphoma Kinase
- Animals
- Cell Line
- Cell Nucleus
- Cell Transformation, Neoplastic
- Chromosomes, Human, Pair 2
- Chromosomes, Human, Pair 5
- Cloning, Molecular
- Cytoplasm
- Enzyme Activation
- Humans
- Lymphoma, Non-Hodgkin
- Mutation
- Nuclear Proteins
- Nucleophosmin