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Detection of t(2;5) in Anaplastic Large Cell Lymphoma

1 Nov 1999

Abstract excerpt

Anaplastic large cell lymphoma (ALCL) is associated with the t(2;5)(p23;q35) translocation involving the anaplastic lymphoma kinase gene (ALK) and the nucleophosmin gene (NPM), which result in expression of a novel fusion protein, NPM-ALK (p80). Clinicopathologic studies have shown that ALK expression in ALCL is associated with improved 5-year survival rates when compared with ALCL lacking ALK expression. This...

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PMID: 10555007
DOI: 10.1097/00000478-199911000-00009

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Detection of t(2;5) in Anaplastic Large Cell LymphomaPMID 10555007Read ↗

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