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Article

Anaplastic lymphoma kinase in human cancer.

Journal of molecular endocrinology - 1 Aug 2011

Barreca Antonella, Lasorsa Elena, Riera Ludovica, Machiorlatti Rodolfo, Piva Roberto, Ponzoni Maurilio, Kwee Ivo, Bertoni Francesco, Piccaluga Pier Paolo, Pileri Stefano A, Inghirami Giorgio

Abstract excerpt

The receptor tyrosine kinases (RTKs) play a critical role, controlling cell proliferation, survival, and differentiation of normal cells. Their pivotal function has been firmly established in the pathogenesis of many cancers as well. The anaplastic lymphoma kinase (ALK), a transmembrane RTK, originally identified in the nucleophosmin (NPM)-ALK chimera of anaplastic large cell lymphoma, has emerged as a novel...

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Identifiers

PMID: 21502284
DOI: 10.1530/JME-11-0004

Genes

ALK

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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