Article

Personalised whole-body modelling links gut microbiota to metabolic perturbations in Alzheimer’s disease

2025-10-29

Abstract excerpt

The human gut microbiome has been linked to metabolic disturbances in Alzheimer’s disease (AD). However, the mechanisms by which gut microbes might influence metabolic dysfunction in AD remain poorly understood. Previously, we used constraint-based metabolic modelling to associate an increased risk of AD with altered production of microbiome-derived metabolites. In this study, we investigated whether these previou...

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Literature Corpus work: 631fdf73-c96e-5cbb-b652-253ad9aacb97
DOI: 10.1101/2025.10.28.685084

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