Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

LAML-Pro: joint maximum likelihood inference of cell genotypes and cell lineage trees.

Bioinformatics (Oxford, England) - 1 Jul 2026

Chu Gillian, Schmidt Henri, Raphael Benjamin J

Abstract excerpt

MOTIVATION: Recent dynamic lineage tracing technologies use genome editing to induce heritable mutations, or edits, that accumulate across successive cell divisions. These edits are measured using single-cell sequencing or imaging, providing data to reconstruct cell lineages at single-cell resolution. Current computational approaches to infer cell lineage trees, or phylogenies, from these data perform two...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Algorithms
Share to Cell Lineage
Share to Computational Biology

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Gene Editing

Share to Genotype

Share to Likelihood Functions

Share to Phylogeny

Share to Single-Cell Analysis

Source

Open in PubMed Open full text

Identifiers

PMID: 42412792
DOI: 10.1093/bioinformatics/btag219
PMCID: PMC13341131

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

LAML-Pro: joint maximum likelihood inference of cell genotypes and cell lineage trees.PMID 42412792Read ↗

Single-cell lineage tracing by integrating CRISPR-Cas9 mutations with transcriptomic data.Semantic proximity Read ↗

High-resolution retrospective single cell lineage tracing with mutable homopolymersSemantic proximity Read ↗

Inference of Single-Cell Phylogenies from Lineage Tracing DataSemantic proximity Read ↗

ScisTree2 enables large-scale inference of cell lineage trees and genotype calling using efficient local search.Semantic proximity Read ↗

ConvexML: Fast and Accurate Branch Length Estimation under Irreversible Mutation Models, Illustrated through Applications to CRISPR/Cas9-Based Lineage Tracing.Semantic proximity Read ↗

A probabilistic framework for cellular lineage reconstruction using single-cell 5-hydroxymethylcytosine sequencingSemantic proximity Read ↗

Evolving strategies for lineage tracing: Genetic markers, synthetic barcodes, and natural variants.Semantic proximity Read ↗

Assessing the inference of single-cell phylogenies and population dynamics from CRISPR lineage recordingsSemantic proximity Read ↗

Maximum likelihood phylogeographic inference of cell motility and cell division from spatial lineage tracing data.Semantic proximity Read ↗

Scuphr: A probabilistic framework for cell lineage tree reconstructionSemantic proximity Read ↗

Charting Single Cell Lineage Dynamics and Mutation Networks via Homing CRISPRSemantic proximity Read ↗

Inference of single-cell phylogenies from lineage tracing data using Cassiopeia.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.