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Article

Mammalian NOTCH-1 activates beta1 integrins via the small GTPase R-Ras.

The Journal of biological chemistry - 28 Sept 2007

Hodkinson Philip S, Elliott Paul A, Lad Yatish, McHugh Brian J, MacKinnon Alison C, Haslett Christopher, Sethi Tariq

Abstract excerpt

Notch is a central regulator of important cell fate decisions. Notch activation produces diverse cellular effects suggesting the presence of context-dependent control mechanisms. Genetic studies have demonstrated that Notch and integrin mutations have related phenotypes in key developmental processes such as vascular development and somitogenesis. We show that the intracellular domain of mammalian Notch-1...

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PMID: 17664272
DOI: 10.1074/jbc.M703601200

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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