Article

APOL1 G1 and G2 risk alleles modulate severity of diet-induced obesity in a transgenic mouse model

2025-12-25

Abstract excerpt

<h4>ABSTRACT</h4> APOL1 G1 and G2 risk alleles are associated with an increased risk of chronic kidney disease. However, a causal relationship between these alleles and cardiometabolic traits has not been experimentally validated. To address this gap, we placed transgenic APOL1 G0, G1, and G2 FVB/NJ mice on a high-fat diet and analyzed them for weight gain as well as obesity-related cardiometabolic phenotypes. T...

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Literature Corpus work: 62db4c39-d14a-56a0-8946-ff68ec994981
DOI: 10.64898/2025.12.23.696293

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