Article
The circadian clock gene BMAL1 is a novel therapeutic target for malignant pleural mesothelioma
17 Apr 2012
Abstract excerpt
Malignant pleural mesothelioma (MPM) is a highly aggressive neoplasm arising from the mesothelial cells lining the parietal pleura and it exhibits poor prognosis. Although there has been significant progress in MPM treatment, development of more efficient therapeutic approaches is needed. BMAL1 is a core component of the circadian clock machinery and its constitutive overexpression in MPM has been reported. Here,...
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