BAP1 is a novel regulator of HIF-1α.

doi:10.1073/pnas.2217840120

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Article

BAP1 is a novel regulator of HIF-1α.

Proceedings of the National Academy of Sciences of the United States of America - 24 Jan 2023

Bononi Angela, Wang Qian, Zolondick Alicia A, Bai Fang, Steele-Tanji Mika, Suarez Joelle S, Pastorino Sandra, Sipes Abigail, Signorato Valentina, Ferro Angelica, Novelli Flavia, Kim Jin-Hee, Minaai Michael, Takinishi Yasutaka, Pellegrini Laura, Napolitano Andrea, Xu Ronghui, Farrar Christine, Goparaju Chandra, Bassi Cristian, Negrini Massimo, Pagano Ian, Sakamoto Greg, Gaudino Giovanni, Pass Harvey I, Onuchic José N, Yang Haining, Carbone Michele

Abstract excerpt

BAP1 is a powerful tumor suppressor gene characterized by haplo insufficiency. Individuals carrying germline BAP1 mutations often develop mesothelioma, an aggressive malignancy of the serosal layers covering the lungs, pericardium, and abdominal cavity. Intriguingly, mesotheliomas developing in carriers of germline BAP1 mutations are less aggressive, and these patients have significantly improved survival. We...

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Identifiers

PMID: 36656861
DOI: 10.1073/pnas.2217840120
PMCID: PMC9942908

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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