Article

Structure of the rabies virus glycoprotein trimer bound to a pre-fusion specific neutralizing antibody

2021-11-16

Abstract excerpt

Rabies infection is nearly 100% lethal if untreated and kills over 50,000 people annually, many of them children. Existing rabies vaccines target the rabies virus glycoprotein (RABV-G) but generate short-lived immune responses, likely because the protein is heterogeneous under physiological conditions. Here, we report the 3.39Å cryo-EM structure of trimeric, pre-fusion RABV-G complexed with RVA122, a potently neut...

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Identifiers and source

Literature Corpus work: 62d6ed4b-eac8-51b1-af70-a69c5eeeebac
DOI: 10.1101/2021.11.16.468852

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