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Structure of tick-borne encephalitis virus and its neutralization by a monoclonal antibody

24 Jan 2018

Abstract excerpt

Tick-borne encephalitis virus (TBEV) causes 13,000 cases of human meningitis and encephalitis annually. However, the structure of the TBEV virion and its interactions with antibodies are unknown. Here, we present cryo-EM structures of the native TBEV virion and its complex with Fab fragments of neutralizing antibody 19/1786. Flavivirus genome delivery depends on membrane fusion that is triggered at low pH. The...

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PMID: 29382836
DOI: 10.1038/s41467-018-02882-0

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