Article

Cell-intrinsic ceramides determine T cell function during melanoma progression

2022-09-03

Abstract excerpt

Acid sphingomyelinase (Asm) and acid ceramidase (Ac) are parts of the sphingolipid metabolism. Asm hydrolyzes sphingomyelin to ceramide, which is further metabolized to sphingosine by Ac. Ceramide generates ceramide-enriched platforms that are involved in receptor clustering within cellular membranes. However, the impact of cell-intrinsic ceramide on T cell function is not well characterized. By using T cell-speci...

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Literature Corpus work: 62c79882-2b58-520d-abb0-a32a55c1dabc
DOI: 10.1101/2022.08.31.505996

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