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Complete Acid Ceramidase ablation prevents cancer-initiating cell formation in melanoma cells

1 Aug 2017

Abstract excerpt

Acid ceramidase (AC) is a lysosomal cysteine hydrolase that catalyzes the conversion of ceramide into fatty acid and sphingosine. This reaction lowers intracellular ceramide levels and concomitantly generates sphingosine used for sphingosine-1-phosphate (S1P) production. Since increases in ceramide and consequent decreases of S1P reduce proliferation of various cancers, AC might offer a new target for anti-tumor...

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PMID: 28785021
DOI: 10.1038/s41598-017-07606-w

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