Article

Co-expression of calcium channels and delayed rectifier potassium channels protects the heart from proarrhythmic events

2019-06-05

Abstract excerpt

Cardiac electrical activity is controlled by the carefully orchestrated activity of more than a dozen different ion conductances. Yet, there is considerable variability in cardiac ion channel expression levels both within and between subjects. In this study we tested the hypothesis that variations in ion channel expression between individuals are not random but rather there are modules of co-expressed genes and th...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work: 62a4a324-ab95-5895-993f-4c39fe4ce7f2
DOI: 10.1101/659821

Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest

Co-expression of calcium channels and delayed rectifier potassium channels protects the heart from proarrhythmic eventsDOI 10.1101/659821Read

Co-expression of calcium and hERG potassium channels reduces the incidence of proarrhythmic eventsSemantic proximity Read

Ion channel expression and electrophysiology of singular human (primary and induced pluripotent stem cell derived) cardiomyocytesSemantic proximity Read

Cardiac Cell Type-Specific Gene Regulatory Programs and Disease Risk AssociationSemantic proximity Read

Common and Rare Variant Contributions to Bradyarrhythmias from Multi-Ancestry Meta-AnalysesSemantic proximity Read

Leveraging the shared and opposing genetic mechanisms in the heritable cardiomyopathiesSemantic proximity Read

Electrophysiological Phenotyping of hiPSC-Derived Atrial Cardiomyocytes Using Automated Patch-Clamp: A Platform for Studying Atrial Inherited Arrhythmias.Semantic proximity Read

Comparative transcriptomics analysis of histone deacetylases, transcription factors, and ion channel genes in human iPSC-cardiomyocytes vs. the adult human heartSemantic proximity Read

A combined genomic arrhythmia propensity score delineates cumulative risk.Semantic proximity Read

PR interval genome-wide association meta-analysis identifies 50 loci associated with atrial and atrioventricular electrical activitySemantic proximity Read

Multi-ancestry GWAS of the electrocardiographic PR interval identifies 210 loci underlying cardiac conductionSemantic proximity Read

mRNA Expression Levels in Failing Human Hearts Predict Cellular Electrophysiological Remodeling: A Population-Based Simulation StudySemantic proximity Read

Genetics and Epigenetics of Atrial FibrillationSemantic proximity Read