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Article

mRNA Expression Levels in Failing Human Hearts Predict Cellular Electrophysiological Remodeling: A Population-Based Simulation Study

20 Feb 2013

Abstract excerpt

Differences in mRNA expression levels have been observed in failing versus non-failing human hearts for several membrane channel proteins and accessory subunits. These differences may play a causal role in electrophysiological changes observed in human heart failure and atrial fibrillation, such as action potential (AP) prolongation, increased AP triangulation, decreased intracellular calcium transient (CaT)...

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Share to Cardiac electrophysiology and arrhythmias
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PMID: 23437117
DOI: 10.1371/journal.pone.0056359

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