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Article

CRISPR therapeutic tools for complex genetic disorders and cancer (Review).

International journal of oncology - 1 Aug 2018

Baliou Stella, Adamaki Maria, Kyriakopoulos Anthony M, Spandidos Demetrios A, Panayiotidis Mihalis, Christodoulou Ioannis, Zoumpourlis Vassilis

Abstract excerpt

One of the fundamental discoveries in the field of biology is the ability to modulate the genome and to monitor the functional outputs derived from genomic alterations. In order to unravel new therapeutic options, scientists had initially focused on inducing genetic alterations in primary cells, in established cancer cell lines and mouse models using either RNA interference or cDNA overexpression or various...

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Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

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Identifiers

PMID: 29901119
DOI: 10.3892/ijo.2018.4434
PMCID: PMC6017271

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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