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The Role of Hypermutation and Collateral Sensitivity in Antimicrobial Resistance Diversity of <i>Pseudomonas aeruginosa</i> Populations in Cystic Fibrosis Lung Infection

2023-06-15

Abstract excerpt

Pseudomonas aeruginosa is an opportunistic pathogen which causes chronic, drug-resistant lung infections in cystic fibrosis (CF) patients. In this study, we explore the role of genomic diversification and evolutionary trade-offs in antimicrobial resistance (AMR) diversity within P. aeruginosa populations sourced from CF lung infections. We analyzed 300 clinical isolates from four CF patients (75 per patient), and...

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Literature Corpus work
62609138-7a13-526a-bb09-28bc5664570b
DOI
10.1101/2023.06.14.544983
Open publication

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The Role of Hypermutation and Collateral Sensitivity in Antimicrobial Resistance Diversity of <i>Pseudomonas aeruginosa</i> Populations in Cystic Fibrosis Lung InfectionDOI 10.1101/2023.06.14.544983
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