Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Drug-Driven Phenotypic Convergence Supports Rational Treatment Strategies of Chronic Infections.

Cell - 11 Jan 2018

Imamovic Lejla, Ellabaan Mostafa Mostafa Hashim, Dantas Machado Ana Manuel, Citterio Linda, Wulff Tune, Molin Soren, Krogh Johansen Helle, Sommer Morten Otto Alexander

Abstract excerpt

Chronic Pseudomonas aeruginosa infections evade antibiotic therapy and are associated with mortality in cystic fibrosis (CF) patients. We find that in vitro resistance evolution of P. aeruginosa toward clinically relevant antibiotics leads to phenotypic convergence toward distinct states. These states are associated with collateral sensitivity toward several antibiotic classes and encoded by mutations in...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Anti-Bacterial Agents
Share to Bacterial Proteins

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Cystic Fibrosis

Share to Drug Resistance, Bacterial

Share to Evolution, Molecular

Share to Pseudomonas aeruginosa

Share to Pseudomonas Infections

Share to Selection, Genetic

Source

Open in PubMed Open full text

Identifiers

PMID: 29307490
DOI: 10.1016/j.cell.2017.12.012
PMCID: PMC5766827

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 3 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Drug-Driven Phenotypic Convergence Supports Rational Treatment Strategies of Chronic Infections.PMID 29307490Read ↗

Hypermutator Pseudomonas aeruginosa Exploits Multiple Genetic Pathways To Develop Multidrug Resistance during Long-Term Infections in the Airways of Cystic Fibrosis Patients.Semantic proximity Read ↗

Pseudomonas aeruginosa Evolutionary Adaptation and Diversification in Cystic Fibrosis Chronic Lung Infections.Semantic proximity Read ↗

Multiple ecological and evolutionary mechanisms drive treatment-induced antibiotic resistanceSemantic proximity Read ↗

Evolutionary Highways to Persistent Bacterial InfectionSemantic proximity Read ↗

Rapid expansion and extinction of antibiotic resistance mutations during treatment of acute bacterial respiratory infections.Semantic proximity Read ↗

Hypermutator <i>Pseudomonas aeruginosa</i> exploits multiple genetic pathways to develop multidrug resistance during long-term infections in the airways of cystic fibrosis patientsSemantic proximity Read ↗

Antibiotics Drive Expansion of Rare Pathogens in a Chronic Infection Microbiome ModelSemantic proximity Read ↗

Development of antibiotic resistance reveals diverse evolutionary pathways to face the complex and dynamic environment of a long-term treated patientSemantic proximity Read ↗

Pseudomonas aeruginosa Diversification during Infection Development in Cystic Fibrosis Lungs—A ReviewSemantic proximity Read ↗

Pseudomonas aeruginosa populations in the cystic fibrosis lung lose susceptibility to newly applied β-lactams within 3 daysSemantic proximity Read ↗

Pseudomonas aeruginosa infection and persistence mechanisms in cystic fibrosis patientsSemantic proximity Read ↗

Evolution of Antibiotic Tolerance Shapes Resistance Development in Chronic Pseudomonas aeruginosa Infections.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.