Article

A non-catalytic function of carbonic anhydrase IX contributes to the glycolytic phenotype and pH regulation in human breast cancer cells

2018-12-24

Abstract excerpt

<h4>ABSTRACT</h4> The most aggressive and invasive tumor cells often reside in hypoxic microenvironments and rely heavily on rapid anaerobic glycolysis for energy production. This switch from oxidative phosphorylation to glycolysis, along with up-regulation of the glucose transport system, significantly increases the release of lactic acid from cells into the tumor microenvironment. Excess lactate and proton excr...

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Literature Corpus work: 62524138-5080-5b6a-a483-f09622a95053
DOI: 10.1101/505644

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