Article

A novel Na <sub>v</sub> 1.5-dependent feedback mechanism driving glycolytic acidification in breast cancer metastasis

2023-06-19

Abstract excerpt

Solid tumours have abnormally high intracellular [Na + ]. The activity of various Na + channels may underlie this Na + accumulation. Voltage-gated Na + channels (VGSCs) have been shown to be functionally active in cancer cell lines, where they promote invasion. However, the mechanisms involved, and clinical relevance, are incompletely understood. Here, we show that protein expression of the Na v 1.5 VGSC subt...

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Literature Corpus work: 05f8c739-dc7d-593e-948f-01223b0cd71d
DOI: 10.1101/2023.06.16.545273

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