Article
Expression and activity of carbonic anhydrase IX is associated with metabolic dysfunction in MDA-MB-231 breast cancer cells.
Cancer investigation - 1 Jul 2009
Li Ying, Wang Hai, Oosterwijk Egbert, Tu Chingkuang, Shiverick Kathleen T, Silverman David N, Frost Susan C
Abstract excerpt
The expression of carbonic anhydrase IX (CAIX), a marker for hypoxic tumors, is correlated with poor prognosis in breast cancer patients. We show herein that the MDA-MB-231 cells, a "triple-negative," basal B line, express exclusively CAIX, while a luminal cell line (T47D) expresses carbonic anhydrase XII (CAXII). CAIX expression in the basal B cells is both density- and hypoxia-dependent and is correlated with...
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