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Exploring mechanisms of mupirocin resistance and hyper-resistance

17 Jun 2024

Abstract excerpt

Mupirocin is a broad-spectrum antibiotic that acts predominantly against Gram-positive bacteria. It is produced by Pseudomonas fluorescens NCIMB 10586 and has been clinically used to treat primary and secondary skin infections and to eradicate nasal colonisation of methicillin-resistant Staphylococcus aureus strains. Mupirocin inhibits protein synthesis by blocking the active site of isoleucyl-tRNA synthetase...

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PMID: 38884776
DOI: 10.1042/bst20230581

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