Article

Patient-derived xenograft culture-transplant system for investigation of human breast cancer metastasis

2020-06-27

Abstract excerpt

Metastasis is a fatal disease where research progress has been hindered by a lack of authentic experimental models. Here, we develop a 3D tumor sphere culture-transplant system that facilitates the expansion and engineering of patient-derived xenograft (PDX) tumor cells for functional metastasis assays in vivo . Orthotopic transplantation and RNA sequencing analyses show that PDX tumor spheres maintain tumorigeni...

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Literature Corpus work: 623eee22-28f5-5797-bb9b-7823011e3b0e
DOI: 10.1101/2020.06.25.172056

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