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Article

A metastasis map of human cancer cell lines.

Nature - 1 Dec 2020

Jin Xin, Demere Zelalem, Nair Karthik, Ali Ahmed, Ferraro Gino B, Natoli Ted, Deik Amy, Petronio Lia, Tang Andrew A, Zhu Cong, Wang Li, Rosenberg Danny, Mangena Vamsi, Roth Jennifer, Chung Kwanghun, Jain Rakesh K, Clish Clary B, Vander Heiden Matthew G, Golub Todd R

Abstract excerpt

Most deaths from cancer are explained by metastasis, and yet large-scale metastasis research has been impractical owing to the complexity of in vivo models. Here we introduce an in vivo barcoding strategy that is capable of determining the metastatic potential of human cancer cell lines in mouse xenografts at scale. We validated the robustness, scalability and reproducibility of the method and applied it to 500...

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Identifiers

PMID: 33299191
DOI: 10.1038/s41586-020-2969-2
PMCID: PMC8439149

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