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Longitudinal accumulation of <i>in vivo</i> and <i>in vitro-</i> grown <i>Treponema pallidum</i> subsp. <i>pallidum</i> TprK variants in the presence and absence of immune pressure

2021-06-27

Abstract excerpt

Immune evasion by Treponema pallidum subspecies pallidum ( T. pallidum ) has been attributed to antigenic variation of its putative outer-membrane protein TprK. In TprK, amino acid diversity is confined to seven variable (V) regions, and generation of sequence diversity within the V regions occurs via a non-reciprocal segmental gene conversion mechanism where donor cassettes recombine into the tprK expression...

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Literature Corpus work
620371fc-8c27-59e9-9b0e-eedae3433113
DOI
10.1101/2021.06.26.450029
Open publication

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Longitudinal accumulation of <i>in vivo</i> and <i>in vitro-</i> grown <i>Treponema pallidum</i> subsp. <i>pallidum</i> TprK variants in the presence and absence of immune pressureDOI 10.1101/2021.06.26.450029
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