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<i>Treponema pallidum</i> subsp. <i>pallidum</i> with an Artificially Impaired TprK Antigenic Variation System is Attenuated in the Rabbit Model of Syphilis

2023-01-18

Abstract excerpt

<h4>Background</h4> The TprK protein of the syphilis agent, Treponema pallidum subsp. pallidum ( T. pallidum ), undergoes antigenic variation in seven discrete variable (V) regions via non-reciprocal segmental gene conversion. These recombination events transfer information from a repertoire of 53 silent chromosomal donor cassettes (DCs) into the single tprK expression site to continually generate TprK varian...

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Literature Corpus work
dc6a485b-685e-5562-b8e4-0d238639744a
DOI
10.1101/2023.01.18.524629
Open publication

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